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Allometry of Hepatic Metabolism of Vinblastine in Dogs, 2009

Principal investigator: Dr. Lara K Maxwell, Oklahoma State University

Vinca alkaloids are chemotherapy drugs used to treat mast cell tumors, a common cancer in dogs. Unfortunately, these drugs work well in less than 50 percent of treated dogs. This low effectiveness may be because the standard drug doses are too low for many dogs. If scientists had a better understanding of the factors that affect how these drugs are cleared from a dog's system, they could make better dosing recommendations based on a dog's size. This study will develop improved methods of individualizing effective doses of vinca alkaloids, allowing more dogs to respond favorably to therapy.