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Effect of High Omega-3 and Low Carbohydrate Diet on Lymphoma Remission and Survival in Dogs, 2015

Principal investigators: Angela Witzel, DVM, PhD, DACVN, University of Tennessee College of Veterinary Medicine and Olya Smrkovski, DVM, DACVIM (Oncology), University of Tennessee College of Veterinary Medicine

Determine if eating a high EPA and DHA diet combined with a low carbohydrate intake increases DFI, survival time, and quality of life in dogs with naturally occurring lymphoma undergoing a standard of care chemotherapy protocol. Assess the palatability and side effects of experimental diets on study subjects.


Tailoring Chemotherapy Treatment, 2010

Principal investigator: Dr. Tomas Martin-Jimenez, University of Tennessee



As companion animals live longer, cancer has become one of the major causes of death. The goal of chemotherapy is to maximize the therapeutic response while minimizing toxic effects. Unfortunately, determining the appropriate dose that each dog needs is difficult. Factors such as age, weight and kidney function influence an animal's response to chemotherapy. This study will discover how these factors affect a dog's response to a chemotherapy commonly used to treat osteosarcomas and carcinomas. They will use this information to develop a dose calculator that would help veterinarians tailor the dose to the specific needs of individual dogs. This would provide more effective treatment and alleviate unwanted side effects.


Population Pharmacokinetics and Pharmacodynamics of Carboplatin in Dogs, 2008-2009

Principal investigator: Dr. Tomas Martin-Jimenez, University of Tennessee

As companion animals live longer, cancer has become one of the major causes of death. The goal of chemotherapy is to maximize the therapeutic response while minimizing toxic effects. Unfortunately, determining the appropriate dose that each dog needs is difficult. Factors such as age, weight and kidney function influence an animal's response to chemotherapy. This study will discover how these factors affect a dog's response to a chemotherapy commonly used to treat osteosarcomas and carcinomas. They will use this information to develop a dose calculator that would help veterinarians tailor the dose to the specific needs of individual dogs. This would provide more effective treatment and alleviate unwanted side effects.